=>
1. In spite of getting up soon, he was late for train.
-> in spite of N/Ving : mặc dù
2. Because of the difficult exam, I couldn't do it.
-> because of N/Ving : bởi vì
3. Because the traffic was bad, we arrived late.
-> because S V : bởi vì
4. Since Nick used to smoke much, his health is worse and worse.
-> since ~ because
5. No matter how long the film is, she spends time watching it.
-> now matter how adj S be : dù thế nào đi nữa
6. Despite getting a good job, he was not happy.
-> despite N/Ving : mặc dù