Lời giải:
1.julie failed the exam_______of working very hard
A.despite B.in spite C.even if D.though
2._______they are brothers they do not look like
A.although B.even C.despite D.in spite of
3.she walked home by herself______she knew that it was dangerous
A.if B.though C.because D.which
4.he refused to give up work ____ he's won a million pounds
A.despite B.however C.even though D. as though