1. Despite the easy test, I couldn't do it.
Despite the fact that it was easy, I couldn't do it.
2. In spite of being an excellent doctor, he can't cure lungcancer.
In spite of the fact that he is an excellent doctor, he can't cure lungcancer.
3. In spite of not having enough money, she wants to buy that new car.
In spite of the fact that my friend doesn't have enough money, she wants to buy that newcar.
4. Although Mai didn't speak English well , she decided to live in London.
→ Although + S + V, S + V: Mặc dù .. nhưng ..
= In spite of/ Despite + N/V_ing, S + V
= In spite of/ Despite + the fact that + S + V, S + V